Synthetic chemistry in the service of meaningful problems
Our group develops small molecules to address unmet needs in medicinal chemistry and chemical biology. Rooted in classical organic synthesis, we design and prepare compounds — from drug candidates to chemical probes and diagnostic tools — that enable biological discoveries and therapeutic development. We believe that synthetic chemistry is most impactful when driven by real biomedical questions, and we pursue this through close collaborations with pharmacologists, biologists, and clinicians. Our work spans infectious disease, metabolic disorders, enzyme inhibition, and targeted protein degradation, united by a common approach: rigorous synthesis in the service of meaningful problems.
Infectious Diseases
Parasitic and viral infections remain among the leading causes of death worldwide, disproportionately affecting low-resource settings. We develop small molecules targeting key stages of pathogen biology — from phenotypic antimalarials to mechanism-based protease inhibitors and targeted degraders.
Antiviral drug discovery — from pathogen to patient.
Chemical Biology & Probes
Understanding biology requires the right tools. We make synthetic small molecules — fluorescent probes, enzyme substrates, and cell wall perturbants — that enable researchers to ask questions that genetics alone cannot answer.
Learn more about our research on chemical biology and probes
Structure-based drug design — small molecule engaging a protein binding pocket.
Enzyme Inhibitors
Enzymes are among the most validated drug target classes. We pursue selective inhibitors across therapeutic areas, guided by structural data and SAR, with applications ranging from cancer to neurodegeneration to skin disorders.
Enzyme inhibitor design — small molecule occupying the active site.
Heterocyclic Chemistry
Heterocycles form the structural core of most pharmaceuticals. We contribute to this field through new synthetic methodology, mechanistic studies, and comprehensive reviews that map the landscape for the community.
Heterocyclic chemistry — from flask to molecular model.